TGen Research - Population Genetics Research Lab

Population Genetics Research Lab

The Population Genetics Research Lab utilizes state-of-the-art genomic analyses and cutting-edge technologies to facilitate discovery of genes associated with disease risk. In collaboration with local, state, national and international researchers, the Lab studies the genetic basis of both common and rare diseases including colon cancer and auriculo-chondylar syndrome (ACS), respectively. The latest genomic resources such as the International HapMap in conjunction with numerous genotyping and liquid handling robotic technologies available in the laboratory are being used to test hypotheses related to SNP and haplotype variation. Furthermore, the latest gene expression technologies are being used to examine the genetic basis of disease at the messenger RNA level.

Current Projects:
1. Common human disease: For example, in collaboration with the National Cancer Institute funded Colon Cancer Family Registry, University of Arizona Cancer Center, University of Southern California and Fred Hutchinson Cancer Research Center, we are testing candidate gene and pathway hypotheses as they pertain to the predisposition of colorectal cancer.

2. Rare human disease: For example, in collaboration with the University of Arizona College of Medicine, we are working to identify the gene mutation or genetic basis of disease for a rare and facial disfiguring congenital abnormality known as ACS.

Staff:
David Duggan, Ph.D., Unit Head
Kristine K. Friesen, Research Associate III
Kathleen Kennedy, Senior Research Associate
Jan Egan, Student, University of Arizona
Jason Johnson, Student, University of Arizona College of Medicine