Breast Cancer Genetics Lab
Breast cancer is the single most common cancer in women. Although early detection followed by resection of tumors have improved the cure frequency, the survival rate sharply declines for patients who have recurring tumors within 5 years of initial treatment. The Breast Cancer Genetics lab focuses on understanding the molecular mechanisms of oncogenes and tumor suppressors involved in the genesis and progression of breast cancer. Our long-term goal is to develop better therapies that target specific molecular lesions associated with individual tumors.
Current Key Projects:
1. Roles for the ING4 tumor suppressor in breast cancer using mouse models.
2. Molecular mechanisms of ING4 tumor suppressor function.
3. Regulation of ING4 by estradiol in breast cancer cells.
4. Transcriptional regulation of tissue kallikreins by ING4 in breast cancer.
5. Development of FISH to detect ING4 deletions in breast cancer using tumor tissue microarrays (TMAs) and correlate with clinical outcome of the patients.
Staff:
Suwon Kim, PhD, Unit Head & Investigator
Tanya Thal, MS, Lab Manager & Research Specialist
Timothy Whitsett, PhD, Post-Doctoral Fellow
Stefanie Raymond-Whish, PhD, Post-Doctoral Fellow
Katie Olson, MDPhD Student
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