Current projects:
1. Gene expression analysis : In collaboration with expert clinicians and physiologists, we are investigating gene expression profiles in response to weight loss, dietary factors (such as high-fructose corn syrup and artificial sweeteners), and exercise.

The questions we are addressing include:

1) What are the pathways, which are activated or repressed as a result of weight loss?

2) What factors determine who is most likely to lose weight and keep it off?

3) What molecular changes accompany the resolution of co-morbidities of obesity, such as insulin resistance, type 2 diabetes, dyslipidemia, and hypertension as a result of bariatric surgery?

2. Other Projects : This Unit also aims to investigate disorders of the gastrointestinal system, particular gastro-esophageal reflux disease, which is strongly heritable, as well as non-alcoholic fatty liver disease.

Staff:
Johanna K. DiStefano, Ph.D., Unit Head
Kimberly A. Yeatts, B.S., Research Associate
Meredith P. Millis, B.S., Research Associate