Cardiovascular Disease Research Unit
Using a multi-ethnic study population and a combination of quantitative trait analysis, meta-analysis, and association studies we are characterizing genes that exert significant effects on the regulation of total cholesterol, LDL, HDL, and triglyceride levels in African Americans, American Indians, Hispanics, and Non-Hispanic Caucasians.
Current Projects:
1. Functional and epidemiological studies : The research mentioned above provides the basis for functional and epidemiological studies to elucidate the genetic mechanisms of lipid metabolism and determines the population-level consequences of important variants. This understanding is essential for efforts to address lipid-related risk factors for coronary heart disease, which is the leading cause of death among individuals with type 2 diabetes.
2. Other projects : Other projects in this unit include reducing susceptibility to chronic inflammation, a state that strongly predisposes to atherosclerosis, and assessing genetic determinants of inflammation.
Staff
Johanna K. DiStefano, Ph.D., Unit Head
Chris Kingsley, Ph.D., Associate Investigator
Kimberly A. Yeatts, B.S., Research Associate
Meredith P. Millis, B.S., Research Associate
Beth Bahe, B.S., Research Associate
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